Introduction: There is increasing of the incidence of chronic subdural hematomas\n(CSDH), due to increase of the elderly population with increase of\nintake oral anticoagulation and antiplatelet drugs in this category of patients.\nSeizures occur as a complication in 2.3% to 20.4% of the patients. There is a\nconsiderable side effect associated with using of anti-epileptic drugs (AEDs).\nAim of the Study: To rule the value of prophylactic antiepileptic drugs in\nprevention of seizures after surgical evacuation of chronic subdural hematoma.\nMethods: A prospective controlled non-randomized study was performed\non 26 patients with chronic or subacute subdural hematoma that was\nsurgically evacuated through burr-holes from April 2017 to June 2019. We\ndivided the patients into 2 groups: group A patients received prophylactic antiepileptic\ndrugs for 6 month and group B patients didnâ??t receive prophylactic\nantiepileptic drugs and the 2 groups were observed to detect occurrence of\npost-operative seizures for 6-month follow-up after surgery. Medical history,\ndemographic data and imaging characteristics were recorded. Results: Seizure\nprevalence for all patients during hospitalization and 6-month follow-up\nwas zero among the 13 patients who received prophylactic anti-seizure medications,\nand was 1 (7.7%) among the 13 patients who didnâ??t receive prophylactic\nanti-seizure medications. Conclusions: The incidence of post-operative\nseizures in patients with chronic subdural hematoma operated upon by burr\nholes evacuation is low. The administration of prophylactic antiepileptic\ndrugs decreases the incidence of seizures after evacuation of CSDH, but the\ndifference was not significant. So prophylactic antiepileptic drugs should not\nbe routinely given for all patients with CSDH operated upon by burr hole\nevacuation unless there is risk factor for seizure development.
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